Catalytic amidation of unactivated ester derivatives mediated by trifluoroethanol

A catalytic amidation method has been developed, employing 2,2,2-trifluoroethanol to facilitate condensation of unactivated esters and amines, enabling the synthesis of a range of amide products in good to excellent yields. Mechanistic studies indicate the reaction proceeds through a trifluoroethanol-derived active ester intermediate

Astro2020 Science White Paper: Cosmology with a Space-Based Gravitational Wave Observatory

There are two big questions cosmologists would like to answer -- How does the Universe work, and what are its origin and destiny? A long wavelength gravitational wave detector -- with million km interferometer arms, achievable only from space -- gives a unique opportunity to address both of these questions. A sensitive, mHz frequency observatory could use the inspiral and merger of massive black hole binaries as standard sirens, extending our ability to characterize the expansion history of the Universe from the onset of dark energy-domination out to a redshift z ~ 10. A low-frequency detector, furthermore, offers the best chance for discovery of exotic gravitational wave sources, including a primordial stochastic background, that could reveal clues to the origin of our Universe.Comment: White Paper submitted on March 8, 2019 to Astro2020 (2020 Decadal Survey on Astronomy and Astrophysics

Amidation of unactivated ester derivatives mediated by trifluoroethanol

A catalytic amidation protocol mediated by 2,2,2-trifluoroethanol has been developed, facilitating the condensation of unactivated esters and amines, furnishing both secondary and tertiary amides. The complete scope and limitations of the method are described, along with modified conditions for challenging substrates such as acyclic secondary amines and chiral esters with retention of chiral integrity

Study protocol to investigate the effect of a lifestyle intervention on body weight, psychological health status and risk factors associated with disease recurrence in women recovering from breast cancer treatment

Background Breast cancer survivors often encounter physiological and psychological problems related to their diagnosis and treatment that can influence long-term prognosis. The aim of this research is to investigate the effects of a lifestyle intervention on body weight and psychological well-being in women recovering from breast cancer treatment, and to determine the relationship between changes in these variables and biomarkers associated with disease recurrence and survival. Methods/design Following ethical approval, a total of 100 patients will be randomly assigned to a lifestyle intervention (incorporating dietary energy restriction in conjunction with aerobic exercise training) or normal care control group. Patients randomised to the dietary and exercise intervention will be given individualised healthy eating dietary advice and written information and attend moderate intensity aerobic exercise sessions on three to five days per week for a period of 24 weeks. The aim of this strategy is to induce a steady weight loss of up to 0.5 Kg each week. In addition, the overall quality of the diet will be examined with a view to (i) reducing the dietary intake of fat to ~25% of the total calories, (ii) eating at least 5 portions of fruit and vegetables a day, (iii) increasing the intake of fibre and reducing refined carbohydrates, and (iv) taking moderate amounts of alcohol. Outcome measures will include body weight and body composition, psychological health status (stress and depression), cardiorespiratory fitness and quality of life. In addition, biomarkers associated with disease recurrence, including stress hormones, estrogen status, inflammatory markers and indices of innate and adaptive immune function will be monitored. Discussion This research will provide valuable information on the effectiveness of a practical, easily implemented lifestyle intervention for evoking positive effects on body weight and psychological well-being, two important factors that can influence long-term prognosis in breast cancer survivors. However, the added value of the study is that it will also evaluate the effects of the lifestyle intervention on a range of biomarkers associated with disease recurrence and survival. Considered together, the results should improve our understanding of the potential role that lifestyle-modifiable factors could play in saving or prolonging lives

The Complete Initial Mass Function Down to the Sub-Solar Regime in the Large Magellanic Cloud with Hubble Space Telescope ACS Observations

In this photometric study of the stellar association LH 95 in the Large Magellanic Cloud (LMC) we focus on the pre-main Sequence (PMS) population in order to construct, for the first time, the sub-solar initial mass function (IMF) in the LMC. We use the deepest photometry ever performed in the LMC with the Advanced Camera for Surveys (ACS) on-board the Hubble Space Telescope(HST). We carry out a Monte Carlo technique to subtract the contribution of the general field of LMC and we isolate the central region in the observed area of the association. We study the mass function of its field-subtracted population. For this purpose, we introduce a new set of evolutionary models, derived from the calculations on the evolution of PMS stars by Siess et al. We use these models with our observations of LH 95 to derive the IMF of the system, which is reliably constructed down to 0.43 M_sun, the lowest mass ever observed within reasonable completeness in the Magellanic Clouds. Consequently, its construction offers an outstanding improvement in our understanding of the low-mass star formation in the LMC. The system IMF of LH 95 shows a definite change in its slope at 1 M_sun, where it becomes more shallow. In general, the shape of this IMF agrees very well with the average Galactic IMF, down to the sub-solar regime. As far as the slope of this system IMF is concerned, it is found to be somewhat more shallow than the corresponding classical Galactic IMF in the sub-solar regime, probably due to unresolved binarity, while for stars with M>1M_sun it becomes slightly steeper. We do not find significant differences in the shape of the overall IMF of LH 95 from that of each of the three individual sub-clusters, suggesting that the IMF of LH 95 is not subject to local variability.Comment: 19 pages, 13 figures. Accepted for publication to Ap

Beyond the ostensible: an exploration of barriers to lean implementation and sustainability in healthcare

The barriers to implement lean have been well researched and have generated consistent results; this study identifies these as ostensible barriers. There is a dearth of research that focus on understanding the causes of these ostensible barriers. Thus, this study aims to empirically investigate the deeper causes that produce ostensible barriers to implement lean in emergency areas of the healthcare. To achieve this aim, the paper draws on rich, qualitative data from four different sources of data, using exploratory case studies as the main approach. Undertaking thematic analysis, six main underlying barriers emerge as the root cause of ostensible barriers. The results suggest that addressing each of the underlying barriers in healthcare is likely to support lean implementation and sustainability, by reducing the impact of restraining forces that come from stakeholders and the public healthcare system

The Maintenance of Traditions in Marmosets: Individual Habit, Not Social Conformity? A Field Experiment

Social conformity is a cornerstone of human culture because it accelerates and maintains the spread of behaviour within a group. Few empirical studies have investigated the role of social conformity in the maintenance of traditions despite an increasing body of literature on the formation of behavioural patterns in non-human animals. The current report presents a field experiment with free-ranging marmosets (Callithrix jacchus) which investigated whether social conformity is necessary for the maintenance of behavioural patterns within groups or whether individual effects such as habit formation would suffice.Using a two-action apparatus, we established alternative behavioural patterns in six family groups composed of 36 individuals. These groups experienced only one technique during a training phase and were thereafter tested with two techniques available. The monkeys reliably maintained the trained method over a period of three weeks, despite discovering the alternative technique. Three additional groups were given the same number of sessions, but those 21 individuals could freely choose the method to obtain a reward. In these control groups, an overall bias towards one of the two methods was observed, but animals with a different preference did not adjust towards the group norm. Thirteen of the fifteen animals that discovered both techniques remained with the action with which they were initially successful, independent of the group preference and the type of action (Binomial test: exp. proportion: 0.5, p<0.01).The results indicate that the maintenance of behavioural patterns within groups 1) could be explained by the first rewarded manipulation and subsequent habit formation and 2) do not require social conformity as a mechanism. After an initial spread of a behaviour throughout a group, this mechanism may lead to a superficial appearance of conformity without the involvement of such a socially and cognitively complex mechanism. This is the first time that such an experiment has been conducted with free-ranging primates

The XMM Cluster Survey: evolution of the velocity dispersion–temperature relation over half a Hubble time

We measure the evolution of the velocity dispersion–temperature (σv–TX) relation up to z = 1 using a sample of 38 galaxy clusters drawn from the XMM Cluster Survey. This work improves upon previous studies by the use of a homogeneous cluster sample and in terms of the number of high-redshift clusters included. We present here new redshift and velocity dispersion measurements for 12 z > 0.5 clusters observed with the Gemini Multi Object Spectographs instruments on the Gemini telescopes. Using an orthogonal regression method,we find that the slope of the relation is steeper than that expected if clusters were self-similar, and that the evolution of the normalization is slightly negative, but not significantly different from zero (σv ∝T0.86±0.14E(z)−0.37±0.33). We verify our results by applying our methods to cosmological hydrodynamical simulations. The lack of evolution seen in our data is consistent with simulations that include both feedback and radiative cooling